granulocyte colony-stimulating factor (G-CSF) A substance that stimulates the bone marrow to develop granulocytes (a type of white blood cell). Granulocytes help defend the body against bacteria, viruses and types of fungus. G-CSF is a cytokine found naturally in the body. It can also be made in a lab. G-CSF is a type of biological therapy used in cancer treatment to lower the risk of infection and the need for antibiotics.
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